12/18/2023 0 Comments Antidote for morphine sulfate![]() In such patients, individual dose adjustments are required.įor children with severe cancer pain, a starting dose in the range of 0.2 to 0.8 mg morphine per kg bodyweight 12 hourly is recommended. Usually such increased requirement is of the order of 100%. Patients receiving MST CONTINUS tablets in place of parenteral morphine should be given a sufficiently increased dosage to compensate for any reduction in analgesic effects associated with oral administration. It is recommended that the 200 mg strength is reserved for patients who have already been titrated to a stable analgesic dose using lower strengths of morphine or other opioid preparations. The correct dosage for any individual patient is that which is sufficient to control pain with no, or tolerable, side effects for a full 12 hours. Higher doses should be made, where possible in 30-50% increments as required. Increasing severity of pain will require an increased dosage of the tablets. Patients previously on normal release oral morphine should be given the same total daily dose as MST CONTINUS tablets but in divided doses at 12-hourly intervals. dihydrocodeine) should normally be started on 30 mg 12 hourly. Prior to starting treatment with opioids, a discussion should be held with patients to put in place a strategy for ending treatment with morphine in order to minimise the risk of addiction and drug withdrawal syndrome (see section 4.4).Ī patient presenting with severe pain, uncontrolled by weaker opioids (e.g. ![]() The dosage is dependent upon the severity of the pain, the patient's age and previous history of analgesic requirements. MST CONTINUS tablets should be used at 12-hourly intervals.
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